Mouse Model of Unstable Atherosclerotic Plaque?
نویسندگان
چکیده
منابع مشابه
Mouse model of unstable atherosclerotic plaque?
The study reported in this issue of Arteriosclerosis, Thrombosis, and Vascular Biology by Rosenfeld et al1 is very important in experimental atherosclerosis for 2 reasons. First, the study shows that there is an available murine model that expresses many features of the human plaque that are very relevant to the pathogenesis of clinically significant disease. Second, the study shows that there ...
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Rupture of advanced human atherosclerotic plaques can precipitate coronary thrombosis, myocardial infarction, and sudden death, but insights into the causes and treatment of plaque rupture have been hampered by lack of a suitable animal model. Particularly desirable would be a model of plaque rupture that would take advantage of current and forthcoming mouse mutant alleles. It is therefore of c...
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OBJECTIVE There is increasing evidence supporting the role of platelets in atherosclerotic vascular disease. The G-protein-coupled receptor P2Y12 is a central mediator of platelet activation and aggregation but has also been linked to platelet-independent vascular disease. Ticagrelor is an oral P2Y12 antagonist that is used as a standard treatment in patients after acute myocardial infarction. ...
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ژورنال
عنوان ژورنال: Arteriosclerosis, Thrombosis, and Vascular Biology
سال: 2000
ISSN: 1079-5642,1524-4636
DOI: 10.1161/01.atv.20.12.2503